BackgroundThe areas of Research Ethics (RE) and Research Integrity (RI) are rapidly evolving. Cases of research misconduct, other transgressions related to RE and RI, and forms of ethically questionable behaviors have been frequently published. The objective of this scoping review was to collect RE and RI cases, analyze their main characteristics, and discuss how these cases are represented in the scientific literature.MethodsThe search included cases involving a violation of, or misbehavior, poor judgment, or detrimental research practice in relation to a (...) normative framework. A search was conducted in PubMed, Web of Science, SCOPUS, JSTOR, Ovid, and Science Direct in March 2018, without language or date restriction. Data relating to the articles and the cases were extracted from case descriptions.ResultsA total of 14,719 records were identified, and 388 items were included in the qualitative synthesis. The papers contained 500 case descriptions. After applying the eligibility criteria, 238 cases were included in the analysis. In the case analysis, fabrication and falsification were the most frequently tagged violations (44.9%). The non-adherence to pertinent laws and regulations, such as lack of informed consent and REC approval, was the second most frequently tagged violation (15.7%), followed by patient safety issues (11.1%) and plagiarism (6.9%). 80.8% of cases were from the Medical and Health Sciences, 11.5% from the Natural Sciences, 4.3% from Social Sciences, 2.1% from Engineering and Technology, and 1.3% from Humanities. Paper retraction was the most prevalent sanction (45.4%), followed by exclusion from funding applications (35.5%).ConclusionsCase descriptions found in academic journals are dominated by discussions regarding prominent cases and are mainly published in the news section of journals. Our results show that there is an overrepresentation of biomedical research cases over other scientific fields compared to its proportion in scientific publications. The cases mostly involve fabrication, falsification, and patient safety issues. This finding could have a significant impact on the academic representation of misbehaviors. The predominance of fabrication and falsification cases might diverge the attention of the academic community from relevant but less visible violations, and from recently emerging forms of misbehaviors. (shrink)

In this paper our aim is to examine whether research conducted on human participants with LSD-25 raises unique research ethical questions or demands particular concerns with regard to the design, conduct and follow-up of these studies, and should this be the case, explore and describe those issues. Our analysis is based on reviewing publications up to date which examine the clinical, research and other uses of LSD and those addressing ethical and methodological concerns of these applications, just as some historical (...) examinations of this subject. The first chapters of the paper give an overview regarding the history of LSD-research with human participants, healthy volunteers and patients alike. The remaining chapters have a focus on questions regarding the potential ethical issues of such human trials in the contemporary research ethics framework. We also consider briefly political and regulatory issues regarding this substance that possibly affect its clinical and research applications. (shrink)

We present the first comprehensive taxonomic revision and review the biology of the olingos, the endemic Neotropical procyonid genus Bassaricyon, based on most specimens available in museums, and with data derived from anatomy, morphometrics, mitochondrial and nuclear DNA, field observations, and geographic range modeling. Species of Bassaricyon are primarily forest-living, arboreal, nocturnal, frugivorous, and solitary, and have one young at a time. We demonstrate that four olingo species can be recognized, including a Central American species (Bassaricyon gabbii), lowland species with (...) eastern, cis-Andean (Bassaricyon alleni) and western, trans-Andean (Bassaricyon medius) distributions, and a species endemic to cloud forests in the Andes. The oldest evolutionary divergence in the genus is between this last species, endemic to the Andes of Colombia and Ecuador, and all other species, which occur in lower elevation habitats. Surprisingly, this Andean endemic species, which we call the Olinguito, has never been previously described; it represents a new species in the order Carnivora and is the smallest living member of the family Procyonidae. We report on the biology of this new species based on information from museum specimens, niche modeling, and fieldwork in western Ecuador, and describe four Olinguito subspecies based on morphological distinctions across different regions of the Northern Andes. (shrink)

Intertemporal choice involves deciding between smaller, sooner and larger, later rewards. People tend to prefer smaller rewards that are available earlier to larger rewards available later, a phenomenon referred to as temporal or delay discounting. Despite its ubiquity in human and non-human animals, temporal discounting is subject to considerable individual differences. Here, we provide a critical narrative review of this literature and make suggestions for future work. We conclude that temporal discounting is associated with key socio-economic and health-related variables. Regarding (...) personality, large-scale studies have found steeper temporal discounting to be associated with higher levels of self-reported impulsivity and extraversion; however, effect sizes are small. Temporal discounting correlates negatively with future-oriented cognitive styles and inhibitory control, again with small effect sizes. There are consistent associations between steeper temporal discounting and lower intelligence, with effect sizes exceeding those of personality or cognitive variables, although socio-demographic moderator variables may play a role. Neuroimaging evidence of brain structural and functional correlates is not yet consistent, neither with regard to areas nor directions of effects. Finally, following early candidate gene studies, recent Genome Wide Association Study (GWAS) approaches have revealed the molecular genetic architecture of temporal discounting to be more complex than initially thought. Overall, the study of individual differences in temporal discounting is a maturing field that has produced some replicable findings. Effect sizes are small-to-medium, necessitating future hypothesis-driven work that prioritizes large samples with adequate power calculations. More research is also needed regarding the neural origins of individual differences in temporal discounting as well as the mediating neural mechanisms of associations of temporal discounting with personality and cognitive variables. (shrink)

Stimulating innovation and growth in the so-called ‘creative economy’ is a current policy objective for national regulators. One policy lever traditionally applied to the creative sector is intellectual property, in particular the scope and term of protection offered by copyright. Opposition to expansion and further enclosure of the copyright public domain was previously articulated in terms of access to a commons of information. Since the Hargreaves Review of Intellectual Property in 2011, copyright reform in the UK context is increasingly framed (...) in the language of economics. This paper reviews two prevailing economic theories shaping how policy makers discuss the public domain in debates about IP reform: a welfare economics approach which weighs increases in producer and consumer surplus under different policy configurations and an economics of innovation approach which considers the value of the public domain as a reservoir of ideas for individuals and firms. I argue that economic definitions should be augmented by a consideration of the democratic requirement of access to information. The consequences of this re-figuration of the public domain for the public interest and access to information are discussed. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 39.1 (2001) 139-141 [Access article in PDF] Helen S. Lang. The Order of Nature in Aristotle's Physics: Place and the Elements. Cambridge: Cambridge University Press, 1998. Pp. xii + 324. £40. This is an unsuccessful book. Some of the reasons for its failure are complex, others are more simple. I cannot address all, but shall simply discuss the fundamental claims about four large (...) topical units—about nature, place, void and elemental motion—indicating why they are untenable.Discussing the celebrated definition of nature in Physics II.1, Lang contends that in it the verb kineisthai should be taken in the passive voice, that nature should be understood as a principle or cause of being moved and of being at rest, and not just blandly as a principle of motion and rest. Since Aristotle asserts in Book VIII of the Physics that the elements contain a passive principle of motion (255b30f), Lang's contention would mean that the elements in this respect do not differ from other natural entities. This is highly unlikely, given the systematic contrast of self-moving composite natural entities and simple, unarticulated elemental natures at 255a5-18. Lang goes so far as to assert [End Page 139] that "kineisthai is always passive, not middle (or reflexive), in both Plato and Aristotle" (42). Fortunately, we need not accept this on her word: although kineisthai can be both passive and middle, in some instances (notably in aorist and future), passive and middle forms are different. Accordingly, Lang's claim must be rejected on the basis of the very first passage she helpfully quotes as an "additional example" in n.24 on p.42: Physics VII.1 242a37f employs the middle voice future, kinesétai, and not the passive form, kinethésetai. The passage, teeming with different forms of the verb kineisthai, describes an entity which contains the principle of motion in itself, which moves naturally. This indisputably shows that Lang's contention is wrong.Lang, contrary to the well-entrenched scholarly consensus, claims that place is not the first (=innermost) extremity or first unmoved boundary of the containing body, but the extremity of the first body, i.e., of the celestial sphere. (The transposition of the qualification "first" happens in several, non-conclusive installments, see e.g. 99f, or 106f.) This transposition, however, runs counter to several of Aristotle's stipulations about place. Lang's all-encompassing extremity can only be the common (koinos) place of everything there is, whereas Aristotle is keen on finding the proper or particular (idios) place, a location which contains nothing but the entity itself (209a32-b1). The entirety of the discussion in Physics IV.4-5 attests that it is this latter place which Aristotle defines here: the first place is neither smaller, nor bigger than the thing in place (211a1f, a23-29, a31-33, etc.). Aristotle repeatedly stresses that the extremities of the contained body and its container are "in the same" (211a33f, b11f). This remark surely would be out of place about the remote extremity of the first containing body. It is also repeatedly set out that the direction of explanation is bottom-up, and not top-down, as Lang's all-encompassing universal place would require: it is by being in a particular locus that we can be said to be in (the sphere of) air, and by this in the heaven (209a33-b1, 211a23-26).Lang's proposal is not just theoretically unappealing. The traditional should not be rejected recklessly, without an attentive discussion. After all, it "apparently beg[a]n immediately with Theophrastus," as Lang rather uncannily admits (105), and it was Theophrastus, and not Lang, who studied and worked for decades with Aristotle.A key assertion of the chapter on void also rests on a grave philological blunder. Lang argues that interpreters switched from Aristotle's expression "that through which" (to di' hou) to "medium," thereby surrendering the original net of notions, in which the natural activity of the element impeded the progression of the... (shrink)

Contemporary public discourses are, despite the growing array of technologies and spaces for participation, becoming increasingly characterized by polarization – the formation of two distinct and r...

Fairness in machine learning (ML) is an ever-growing field of research due to the manifold potential for harm from algorithmic discrimination. To prevent such harm, a large body of literature develops new approaches to quantify fairness. Here, we investigate how one can divert the quantification of fairness by describing a practice we call “fairness hacking” for the purpose of shrouding unfairness in algorithms. This impacts end-users who rely on learning algorithms, as well as the broader community interested in fair AI (...) practices. We introduce two different categories of fairness hacking in reference to the established concept of p-hacking. The first category, intra-metric fairness hacking, describes the misuse of a particular metric by adding or removing sensitive attributes from the analysis. In this context, countermeasures that have been developed to prevent or reduce p-hacking can be applied to similarly prevent or reduce fairness hacking. The second category of fairness hacking is inter-metric fairness hacking. Inter-metric fairness hacking is the search for a specific fair metric with given attributes. We argue that countermeasures to prevent or reduce inter-metric fairness hacking are still in their infancy. Finally, we demonstrate both types of fairness hacking using real datasets. Our paper intends to serve as a guidance for discussions within the fair ML community to prevent or reduce the misuse of fairness metrics, and thus reduce overall harm from ML applications. (shrink)

What if language was an autonomous historical being? What if language’s use was not solely dependent on the intentions of the one who speaks? In this text I will test these provocative statements. Specifically, I will investigate whether language’s proclaimed historical independence can be traced in the usage of the concept of ‘secularisation’, and I will try to unveil the consequences of this operation.Contribution: Has Christianity abandoned the public stage in the ‘secularised’ and industrialised world? In this article I intend (...) to demonstrate that this is not the case. The continuous operative presence of Christianity in our socio-political language is used as the model to prove this argument. (shrink)

As narrative conceptions of selfhood have gained more acceptance within various disciplines including philosophy, psychology, and the cognitive sciences, so too have these conceptions been critically appraised. Chief among those who are suspicious of the overall viability of ‘narrative identity’ is the philosopher, Galen Strawson. In this paper, I develop five arguments underlying Strawson’s critique of narrative identity, and respond to each argument from the perspective of the hermeneutic phenomenology of Paul Ricœur. Though intuitive, I demonstrate that none of Strawson’s (...) arguments are cogent. The confrontation between these two figures highlights a deep conceptual disagreement about our epistemic access to the self, which has thus far gone unrecognized in the Anglo-American discussion, so that it raises a new problem for the metaphysics of personal identity. (shrink)

Scholar of religion Karl Kerényi’s last book, Dionysos, is a grand attempt at reinterpreting ζωη ( zoe ), the Greek concept of indestructible life, which he distinguishes from βίος (bios), finite life. In Kerényi’s view, the meaning and sensual experience of zoe was expressed in its richest form in the Cretan beginnings of the cult of Dionysos. The major characteristics of this cult, as Kerényi describes, were beyond the cultural, political, and sexual limits of the Christian interpretations of life and (...) nature. Searching for modern analogies to zoe , Kerényi explains the idea in relation to molecular biology’s minimum definition of life. Despite the fact that Kerényi’s book contains only minor references to contemporary philosophy, the philosophical consequences of his interpretations of Dionysos are not only radical but outline a notion of biopolitics far in advance of the mid- to late 20 th -century development of it. By the affirmation of indestructible life and animality , Kerényi proposes a new humanism that moves beyond the limits of Kantian anthropology and also takes a radically different perspective to that of Heidegger’s philosophy of being, or Agamben’s notion of biopolitics. According to Kerényi’s investigations, since this alternative humanism, which is based on the radical recognition of the individuality and diversity of life forms, was once possible in an earlier stage of human culture, it is possible to reanimate it in order to shape anew how zoe is understood and therefore lived. Our relation to nature can thereby undergo a Dionysian transvaluation and assign us new responsibilities as well as open up a new trajectory for the 21 st -century human. (shrink)

BackgroundRich in different kind of potent cells, embryos are used in modern regenerative medicine and research. Neurobiologists today are pushing the boundaries for what can be done with embryos existing in the transitory margins of medicine. Therefore, there is a growing need to develop conceptual frameworks for interpreting the transformative cultural, biological and technical processes involving these aborted, donated and marginal embryos. This article is a contribution to this development of frameworks.MethodsThis article examines different emotional, cognitive and discursive strategies used (...) by neurobiologists in a foetal cell transplantation trial in Parkinson’s disease research, using cells harvested from aborted embryos. Two interviews were analysed in the light of former observations in the processing laboratories, using the anthropologist Mary Douglas’s concept of pollution behaviour and the linguist, philosopher, psychoanalyst and feminist Julia Kristeva’s concept of the abjective to explain and make sense of the findings.ResultsThe findings indicate that the labour performed by the researchers in the trial work involves transforming the foetal material practically, as well as culturally, from trash to treasure. The transformation process contains different phases, and in the interview material we observed that the foetal material or cells were considered objects, subjects or rejected as abject by the researchers handling them, depending on what phase of process or practice they referred to or had experience of. As demonstrated in the analysis, it is the human origin of the cell that makes it abjective and activates pollution discourse, when the researchers talk of their practice.ConclusionsThe marginal and ambiguous status of the embryo that emerges in the accounts turns the scientists handling foetal cells into liminal characters in modern medicine. Focusing on how practical as well as emotional and cultural strategies and rationalizations of the researchers emerge in interview accounts, this study adds insights on the rationale of practically procuring, transforming and utilizing the foetal material to the already existing studies focused on the donations. We also discuss why the use and refinement of a tissue, around which there is practical consensus but cultural ambiguity, deserves further investigation. (shrink)

RésuméLa théorie avicenienne du mouvement des orbes célestes représente un aspect important de sa cosmologie qui n'a cependant pas encore été l'objet d'une étude approfondie. Cet article compte combler ce manque en fournissant une analyse des différents principes à l'origine du mouvement céleste, ainsi qu'une réflexion sur le rôle des disciplines astronomique, physique, et métaphysique dans les explications que fournit Ibn Sīnā à ce sujet. L'accent est mis sur le rapport des intelligences aux orbes et sur la problématique du passage (...) de l'intellectif au physique, un moment charnière dans la cinématique avicenienne. En outre, l'étude remet en question l'adhésion d'Ibn Sīnā à la théorie farabienne des dix intelligences et entreprend une reconstitution de son modèle cosmologique. (shrink)

The application of evolutionary perspectives to analyzing sex differences in aggressive behavior and dominance hierarchies has been found useful in multiple areas. We draw attention to the parallel of gender differences in the worsening health status of restructuring societies. Drastic socio-economic changes are interpreted as examples of hierarchy disruption, having differential psychological and behavioral impact on women and men, and leading to different changes in health status.

In all kinds of implementations of computing, whether technological or biological, some material carrier for the information exists, so in real-world implementations, the propagation speed of information cannot exceed the speed of its carrier. Because of this limitation, one must also consider the transfer time between computing units for any implementation. We need a different mathematical method to consider this limitation: classic mathematics can only describe infinitely fast and small computing system implementations. The difference between mathematical handling methods leads to (...) different descriptions of the computing features of the systems. The proposed handling also explains why biological implementations can have lifelong learning and technological ones cannot. Our conclusion about learning matches published experimental evidence, both in biological and technological computing. (shrink)

The study focuses on the ethical aspects of decision-making by national elites in the context of the thinking of Ján Kollár (1793–1852) and Ľudovít Štúr (1815–1856) on the issue of Slavism. Attention is paid to the issue of responsibility for preserving the greatness and unity of the nation in the context of the formation of national identity and individuality. The concepts of the mentioned authors had an impact on the cultural-civilizational orientation of Slovak elites with an emphasis on the role (...) of moral obligations in shaping the value orientation of the nation. In this context, the analysis focuses on the works Reciprocity between the various tribes and dialects of the Slavic nation and Slavdom and the world of the future, which, at the same time, represent alternative concepts of the cultural and political orientation of the Slavs. The study simultaneously analyses these concepts as alternative programs of cultural and political development of national identity, as well as concepts aimed at humanist and political goals. (shrink)

The dialectical-theological origins of the politically- and ethically-charged concept of alterity are well-known within the philosophy of religion. Intellectual histories of this concept tie it too exclusively to the notion of distance or διάστασις in Karl Barth’s early Römerbrief, however, and so miss Barth’s Trinitarian reinterpretation of God’s otherness in his later work. Taking as my hermeneutical key a cipher, the ‘sign of Jonah,’ that emerges in Church Dogmatics IV/1, I show that Barth’s mature doctrines of temporality and filiation understand (...) alterity as a moment of divine life. Jesus’ agony in the garden of Gethsemane marks the climax of Barth’s self-reinterpretation: world history inheres within the Christological situation of paternal abandonment. The political-theological conclusions Barth draws from the ‘sign of Jonah’ dovetail with alterity discourses’ antitotalitarian aspirations but suggest that these aspirations’ structural coherence rest on the magisterial Reformers’ Christological and ecclesiological commitments. (shrink)

The paper examines the difference between János Bolyai’s and Lobachevskii’s notion of non-Euclidean parallelism. The examination starts with the summary of a widespread view of historians of mathematics on János Bolyai’s notion of non-Euclidean parallelism used in the first paragraph of his Appendix. After this a novel position of the location and meaning of Bolyai’s term “parallela” in his Appendix is put forward. After that János Bolyai’s Hungarian manuscript, the Commentary on Lobachevskii’s Geometrische Untersuchungen is elaborated in (...) order to see how Bolyai and Lobachevskii’s notions of parallelism differ. The careful examination of the Commentary reveals a seeming incoherence of Bolyai’s translation, and finally the explanation of this incoherence offered by the Received View and that of the novel position will be compared and assessed. L’article examine la différence entre la notion du parallélisme non-Euclidean de János Bolyai et celle de Lobachevskii. Tout d’abord le travail s’occupe de l’opinion répendue parmi les historiens de géometrie (le « Received View » ), selon laquelle János Bolyai précise la notion du parallélisme non-Euclidean dans le premier paragraph de l’Appendix. Ensuite une pointe de vue toute neuve sera présentée concernant la place et le sens du terminus technicus,,paralella” de Bolyai dans l’Appendix. Enfin on va analyser les Commentaires (un manuscrit hongrois) de János Bolyai sur le livre Geometrische Untersuchungen de Lobachevskii àfin de voir jusqu’à quel point la notion de parallelisme de Bolyai se diffère de celle de Lobachevskii. L’analyse bien fondue des Commentaires va nous relever un apparent incohérence de la traduction de Bolyai. On examine et on compare l’opinion répendue dans le vaste public avec la nouvelle interpretation de l’Appendix, et on discute les explications probables de cet incohérence. (shrink)

The goal of constructing artificial photosynthetic assemblies is to use sunlight for the generation of hydrogen from water; the hydrogen obtained should be an ideal energy source. The use of surfactant vesicle entrapped‐catalyst coated colloidal semiconductors and sacrificial electron donors for photosensitized water reduction illustrates how chemists mimic photosynthesis.

Though the problem of conceptual idolatry has captivated contemporary scholarship on the relationship between philosophy and theology, these discussions’ doctrinal consequences remain underdeveloped. I intervene in these debates by engaging and elucidating Martin Luther’s critique of scholastic metaphysics, a critique which foregrounds ontotheology’s spiritual and ecclesial detriments. Luther’s reforming works, from his pivotal 1525 De servo arbitrio to his last major project, the 1545 Genesis commentaries, reveal how a metaphysical theology based on natural reason leads to Pelagianism by generalizing faith (...) to a rational conceptual norm, the moral Law. Returning, however, to Scripture’s “grammar” – which, when read plainly, deconstructs natural reason’s vanity – allows us to encounter Christ ‘in person’ rather than in the concept. Luther thus suggests sola scriptura as a method for resisting ontotheology, but with dramatic dogmatic consequences, such as justification by faith alone. These consequences complicate modernity’s, and especially modern philosophy’s, theological origins and implications. (shrink)

Pickering & Garrod (P&G) propose that inner speech monitoring is subserved by predictions stemming from fast forward modeling. In this commentary, we question this alignment of language prediction with the inner speech monitor. We wonder how the speech monitor can function so efficiently if it is based on incomplete representations.

Genesis 2:4–25, the story of the creation of man and woman, has received great attention in modern theology. The text indeed contains the most fundamental teaching of the Bible on the relation between man and woman, on sexuality, and on marriage. In this article, however, I attempt to highlight some of the theoretical/philosophical potential of the text. While I accept the main theological teaching of Genesis 2 about the equality of the sexes, I argue that the text goes beyond the (...) mere presentation of this theological doctrine, and provides a structure that allows for a dynamic interplay between the sexes. I contend, furthermore, that this structure and the ensuing dynamics can be interpreted as a subtle treatment of the issue of the same and the other. Finally, I argue that in this way the biblical text can provide a description of the experience of love and an account of human creativity. In other words, it accounts for the possibility of realizing our divine likeness, the divinity of the human. (shrink)